您好：
What's wrong?
What's the matter?
What's the trouble?
Are you OK?
What happens?
前四种一般是对疾病的提问，第五种是对发生事情的提问，前三个可以在后面加with you
如果对你有帮助，请采纳！祝你学习更上一层楼，数学辅导团为你解决疑问！
What's up？
What's the matter？
what's wrong？
what's going on？
what's happened to you？
what,s up.
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