求翻译成英文

2025-03-05 02:33:33

推荐回答（1个）

回答1：

The macrocyclic polyamine ligands metal mimic hydrolase activity center is a very in-depth study and development of the cutting system. The hydrolysis cleavage in DNA two phosphate ester based on the design, synthesis of monocyclic and polycyclic ring with organic guanidine, amino, hydroxyl group side chain groups of three amines and large ring four amine, mononuclear and multinuclear macrocyclic complexes and synthesis of various metal ions; Determination of complex hydrolysis activity the two phosphate bond model compounds BDNPP and BNPP with the synthetic model, gives the hydrolysis kinetics parameters; with the use of synthetic model complexes of oligonucleotides, DNA identification, cutting research using electrospray ionization mass spectrometry; structure of complexes in solution, provide structural information of coordination compounds as to reveal the cutting mechanism research; expected to obtain some kind of good recognition and cutting function of the new DNA cleavage reagent, and contribute to the complex and hydrolysis of can specifically recognize the DNA cutting properties, characteristics and mechanism of agent has a more in-depth understanding, has provided reference complexes and gene therapy drug DNA cutting function for further development, made some valuable progress in cutting theory and application agent in nucleic acid.

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