感染性肾结石怎样进行内科治疗?

2025-03-26 22:59:47
推荐回答(1个)
回答1:

内科治疗包括一般疗法、对症治疗、抗菌(抑菌)治疗以及中药治疗、食饵疗法。

(1)一般治疗。大量饮水,尽可能使每日尿量维持在2000~3000ml以上。在结石多发地区,每日尿量少于1200ml时,结石生长的危险性显著增大,为了保持夜间尿量,睡前饮水,睡眠中起床排尿后再饮水。大量饮水配合利尿解痉药,可促使小的结石排出。稀释尿可能延缓结石增长速度和手术后结石的再发。特别是对于感染性肾结石,多饮水、勤排尿可促进细菌的排出,有利于感染的控制。在肾绞痛时,多饮水有时虽可加剧绞痛,但如配合针灸和解痉药物,可帮助结石排出。

(2)对症治疗。在肾绞痛时,可采用肌内注射盐酸哌替啶50mg或与异丙嗪25mg并用,症状无好转时,每4小时可注射一次。吗啡10mg和阿托品0.5mg合用也可解痉止痛。针刺疗法强刺激肾俞、京门、三阴交或阿是穴也有解痉止痛的效果。肾区局部热敷可减轻疼痛。

恶心呕吐严重时,应静滴葡萄糖和生理盐水以补充液体和电解质,酸中毒时,予5%碳酸氢钠。

(3)抗(抑)菌疗法。肾结石直径在0.7~1cm以下,表面光滑,有时用内科治疗有效,目前尚无满意的溶石药物。通常需使用对细菌敏感的药物,其次酸化尿液,可使用氯化铵每日3~9g,分3次口服,孟德立胺1g,每日4次,既可酸化尿液,又可杀灭或抑制感染细菌,两药常并用。

选用适当的抗菌药,对控制存在的尿路感染、外科取石的术前尿路消毒及术后根治细菌尿、防止结石的重新形成,都有重要意义。

引起感染性结石的常见致病菌是奇异变形杆菌,故宜首先选用氨苄西林,其次可选用氨基糖苷类抗菌药。对顽固的病例,亦可考虑用氨基糖苷类加四环素类、广谱青霉素类或头孢菌素类。在充分注意到抗菌药毒性的前提下,抗菌药的剂量应尽可能大,这样才能肃清结石内的细菌。若频繁复发或经整个疗程的抗菌治疗仍未能肃清尿中细菌时,宜做一个时期的长疗程法。此外,手术后亦应用6~12个月的抑菌疗法以增加治愈率。

乙酰氧肟酸为尿素酶抑制剂,能抑制细菌的尿毒酶分解尿素,因而,可以降低尿氨和重碳酸盐浓度,降低尿pH值,从而防止磷酸铵镁和磷灰石结晶及沉淀。动物模型证实,抑制氨生成时,变形杆菌的毒力大为减弱,尿液酸化,有利于溶解结石或减慢结石的形成。

用量一般为每日0.75g,分3次服,结合抗生素可提高疗效,但血肌酐超过265μmol/L(3mg/dl)者禁用。

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